Allelic variation contributes to bacterial host specificity

Min Yue, Xiangan Han, Leon De Masi, Chunhong Zhu, Xun Ma, Junjie Zhang, Renwei Wu, Robert Schmieder, Radhey S. Kaushik, George P. Fraser, Shaohua Zhao, Patrick F. McDermott, François-Xavier Weill, Jacques G. Mainil, Cesar Arze, W. Florian Fricke, Robert A. Edwards, Dustin Brisson, Nancy R. Zhang, Shelley C. Rankin and Dieter M. Schifferli ()
Additional contact information
Min Yue: University of Pennsylvania School of Veterinary Medicine
Xiangan Han: University of Pennsylvania School of Veterinary Medicine
Leon De Masi: University of Pennsylvania School of Veterinary Medicine
Chunhong Zhu: University of Pennsylvania School of Veterinary Medicine
Xun Ma: University of Pennsylvania School of Veterinary Medicine
Junjie Zhang: University of Pennsylvania School of Veterinary Medicine
Renwei Wu: University of Pennsylvania School of Veterinary Medicine
Robert Schmieder: College of Sciences, San Diego State University
Radhey S. Kaushik: South Dakota State University
George P. Fraser: Bureau of Laboratories
Shaohua Zhao: Center for Veterinary Medicine, US FDA, Office of Research
Patrick F. McDermott: Center for Veterinary Medicine, US FDA, Office of Research
François-Xavier Weill: Institut Pasteur, Unité des Bactéries Pathogènes Entériques
Jacques G. Mainil: Bacteriology, Faculty of Veterinary Medicine and Institute for Fundamental and Applied Research in Animal Health (FARAH), Campus du Sart Tilman, Bât. B43a, University of Liège
Cesar Arze: Institute for Genome Sciences, University of Maryland School of Medicine
W. Florian Fricke: Institute for Genome Sciences, University of Maryland School of Medicine
Robert A. Edwards: College of Sciences, San Diego State University
Dustin Brisson: School of Art and Science, University of Pennsylvania, 209 Leidy Laboratories, 433S. University Avenue
Nancy R. Zhang: Wharton School, University of Pennsylvania
Shelley C. Rankin: University of Pennsylvania School of Veterinary Medicine
Dieter M. Schifferli: University of Pennsylvania School of Veterinary Medicine

Nature Communications, 2015, vol. 6, issue 1, 1-11

Abstract: Abstract Understanding the molecular parameters that regulate cross-species transmission and host adaptation of potential pathogens is crucial to control emerging infectious disease. Although microbial pathotype diversity is conventionally associated with gene gain or loss, the role of pathoadaptive nonsynonymous single-nucleotide polymorphisms (nsSNPs) has not been systematically evaluated. Here, our genome-wide analysis of core genes within Salmonella enterica serovar Typhimurium genomes reveals a high degree of allelic variation in surface-exposed molecules, including adhesins that promote host colonization. Subsequent multinomial logistic regression, MultiPhen and Random Forest analyses of known/suspected adhesins from 580 independent Typhimurium isolates identifies distinct host-specific nsSNP signatures. Moreover, population and functional analyses of host-associated nsSNPs for FimH, the type 1 fimbrial adhesin, highlights the role of key allelic residues in host-specific adherence in vitro. Together, our data provide the first concrete evidence that functional differences between allelic variants of bacterial proteins likely contribute to pathoadaption to diverse hosts.

Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms9754 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9754

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms9754

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().