Endothelial Gata5 transcription factor regulates blood pressure

Smail Messaoudi, Ying He, Alex Gutsol, Andrew Wight, Richard L. Hébert, Ragnar O. Vilmundarson, Andrew P. Makrigiannis, John Chalmers, Pavel Hamet, Johanne Tremblay, Ruth McPherson, Alexandre F. R. Stewart, Rhian M. Touyz and Mona Nemer ()
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Smail Messaoudi: Faculty of Medicine, Microbiology and Immunology, University of Ottawa
Ying He: Kidney Research Center, University of Ottawa
Alex Gutsol: Kidney Research Center, University of Ottawa
Andrew Wight: Faculty of Medicine, Microbiology and Immunology, University of Ottawa
Richard L. Hébert: Kidney Research Center, University of Ottawa
Ragnar O. Vilmundarson: University of Ottawa Heart Institute, University of Ottawa
Andrew P. Makrigiannis: Faculty of Medicine, Microbiology and Immunology, University of Ottawa
John Chalmers: The George Institute for Global Health, The University of Sydney, The Royal Prince Alfred Hospital
Pavel Hamet: Centre de Recherche du Centre Hospitalier de l’Université de Montréal
Johanne Tremblay: University of Ottawa Heart Institute, University of Ottawa
Ruth McPherson: University of Ottawa Heart Institute, University of Ottawa
Alexandre F. R. Stewart: University of Ottawa Heart Institute, University of Ottawa
Rhian M. Touyz: Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow
Mona Nemer: Faculty of Medicine, Microbiology and Immunology, University of Ottawa

Nature Communications, 2015, vol. 6, issue 1, 1-13

Abstract: Abstract Despite its high prevalence and economic burden, the aetiology of human hypertension remains incompletely understood. Here we identify the transcription factor GATA5, as a new regulator of blood pressure (BP). GATA5 is expressed in microvascular endothelial cells and its genetic inactivation in mice (Gata5-null) leads to vascular endothelial dysfunction and hypertension. Endothelial-specific inactivation of Gata5 mimics the hypertensive phenotype of the Gata5-null mice, suggestive of an important role for GATA5 in endothelial homeostasis. Transcriptomic analysis of human microvascular endothelial cells with GATA5 knockdown reveals that GATA5 affects several genes and pathways critical for proper endothelial function, such as PKA and nitric oxide pathways. Consistent with a role in human hypertension, we report genetic association of variants at the GATA5 locus with hypertension traits in two large independent cohorts. Our results unveil an unsuspected link between GATA5 and a prominent human condition, and provide a new animal model for hypertension.

Date: 2015
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DOI: 10.1038/ncomms9835

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