Optical focusing inside scattering media with time-reversed ultrasound microbubble encoded light

Haowen Ruan (), Mooseok Jang () and Changhuei Yang
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Haowen Ruan: California Institute of Technology
Mooseok Jang: California Institute of Technology
Changhuei Yang: California Institute of Technology

Nature Communications, 2015, vol. 6, issue 1, 1-8

Abstract: Abstract Focusing light inside scattering media in a freely addressable fashion is challenging, as the wavefront of the scattered light is highly disordered. Recently developed ultrasound-guided wavefront shaping methods are addressing this challenge, albeit with relatively low modulation efficiency and resolution limitations. In this paper, we present a new technique, time-reversed ultrasound microbubble encoded (TRUME) optical focusing, which can focus light with improved efficiency and sub-ultrasound wavelength resolution. This method ultrasonically destroys microbubbles, and measures the wavefront change to compute and render a suitable time-reversed wavefront solution for focusing. We demonstrate that the TRUME technique can create an optical focus at the site of bubble destruction with a size of ∼2 μm. We further demonstrate a twofold enhancement in addressable focus resolution in a microbubble aggregate target by exploiting the nonlinear pressure-to-destruction response of the microbubbles. The reported technique provides a deep tissue-focusing solution with high efficiency, resolution, and specificity.

Date: 2015
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DOI: 10.1038/ncomms9968

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