Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius

Jeffrey A. Rosenfeld, Darryl Reeves, Mercer R. Brugler, Apurva Narechania, Sabrina Simon, Russell Durrett, Jonathan Foox, Kevin Shianna, Michael C. Schatz, Jorge Gandara, Ebrahim Afshinnekoo, Ernest T. Lam, Alex R. Hastie, Saki Chan, Han Cao, Michael Saghbini, Alex Kentsis, Paul J. Planet, Vladyslav Kholodovych, Michael Tessler, Richard Baker, Rob DeSalle, Louis N. Sorkin, Sergios-Orestis Kolokotronis, Mark E. Siddall (), George Amato () and Christopher E. Mason ()
Additional contact information
Jeffrey A. Rosenfeld: Sackler Institute for Comparative Genomics, American Museum of Natural History
Darryl Reeves: Weill Cornell Medical College
Mercer R. Brugler: Sackler Institute for Comparative Genomics, American Museum of Natural History
Apurva Narechania: Sackler Institute for Comparative Genomics, American Museum of Natural History
Sabrina Simon: Sackler Institute for Comparative Genomics, American Museum of Natural History
Russell Durrett: Weill Cornell Medical College
Jonathan Foox: Sackler Institute for Comparative Genomics, American Museum of Natural History
Kevin Shianna: Illumina Inc. 5200 Illumina Way
Michael C. Schatz: Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory
Jorge Gandara: Weill Cornell Medical College
Ebrahim Afshinnekoo: Weill Cornell Medical College
Ernest T. Lam: BioNanoGenomics Inc. 9640 Towne Centre Drive Ste. 100
Alex R. Hastie: BioNanoGenomics Inc. 9640 Towne Centre Drive Ste. 100
Saki Chan: BioNanoGenomics Inc. 9640 Towne Centre Drive Ste. 100
Han Cao: BioNanoGenomics Inc. 9640 Towne Centre Drive Ste. 100
Michael Saghbini: BioNanoGenomics Inc. 9640 Towne Centre Drive Ste. 100
Alex Kentsis: Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Paul J. Planet: Sackler Institute for Comparative Genomics, American Museum of Natural History
Vladyslav Kholodovych: High Performance and Research Computing Group, Rutgers Biomedical and Health Sciences
Michael Tessler: Sackler Institute for Comparative Genomics, American Museum of Natural History
Richard Baker: Sackler Institute for Comparative Genomics, American Museum of Natural History
Rob DeSalle: Sackler Institute for Comparative Genomics, American Museum of Natural History
Louis N. Sorkin: American Museum of Natural History
Sergios-Orestis Kolokotronis: Sackler Institute for Comparative Genomics, American Museum of Natural History
Mark E. Siddall: Sackler Institute for Comparative Genomics, American Museum of Natural History
George Amato: Sackler Institute for Comparative Genomics, American Museum of Natural History
Christopher E. Mason: Weill Cornell Medical College

Nature Communications, 2016, vol. 7, issue 1, 1-10

Abstract: Abstract The common bed bug (Cimex lectularius) has been a persistent pest of humans for thousands of years, yet the genetic basis of the bed bug’s basic biology and adaptation to dense human environments is largely unknown. Here we report the assembly, annotation and phylogenetic mapping of the 697.9-Mb Cimex lectularius genome, with an N50 of 971 kb, using both long and short read technologies. A RNA-seq time course across all five developmental stages and male and female adults generated 36,985 coding and noncoding gene models. The most pronounced change in gene expression during the life cycle occurs after feeding on human blood and included genes from the Wolbachia endosymbiont, which shows a simultaneous and coordinated host/commensal response to haematophagous activity. These data provide a rich genetic resource for mapping activity and density of C. lectularius across human hosts and cities, which can help track, manage and control bed bug infestations.

Date: 2016
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DOI: 10.1038/ncomms10164

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