Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Charlotte L. Scott, Fang Zheng, Patrick De Baetselier, Liesbet Martens, Yvan Saeys, Sofie De Prijck, Saskia Lippens, Chloé Abels, Steve Schoonooghe, Geert Raes, Nick Devoogdt, Bart N. Lambrecht, Alain Beschin and Martin Guilliams ()
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Charlotte L. Scott: Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
Fang Zheng: Myeloid Cell Immunology, VIB
Patrick De Baetselier: Myeloid Cell Immunology, VIB
Liesbet Martens: Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
Yvan Saeys: Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
Sofie De Prijck: Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
Saskia Lippens: Ghent University
Chloé Abels: Myeloid Cell Immunology, VIB
Steve Schoonooghe: Myeloid Cell Immunology, VIB
Geert Raes: Myeloid Cell Immunology, VIB
Nick Devoogdt: Cellular and Molecular Immunology Research Group, Vrije Universiteit Brussel
Bart N. Lambrecht: Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center
Alain Beschin: Myeloid Cell Immunology, VIB
Martin Guilliams: Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center

Nature Communications, 2016, vol. 7, issue 1, 1-10

Abstract: Abstract Self-renewing tissue-resident macrophages are thought to be exclusively derived from embryonic progenitors. However, whether circulating monocytes can also give rise to such macrophages has not been formally investigated. Here we use a new model of diphtheria toxin-mediated depletion of liver-resident Kupffer cells to generate niche availability and show that circulating monocytes engraft in the liver, gradually adopt the transcriptional profile of their depleted counterparts and become long-lived self-renewing cells. Underlining the physiological relevance of our findings, circulating monocytes also contribute to the expanding pool of macrophages in the liver shortly after birth, when macrophage niches become available during normal organ growth. Thus, like embryonic precursors, monocytes can and do give rise to self-renewing tissue-resident macrophages if the niche is available to them.

Date: 2016
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DOI: 10.1038/ncomms10321

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