Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts

Emilie Abby, Sophie Tourpin, Jonathan Ribeiro, Katrin Daniel, Sébastien Messiaen, Delphine Moison, Justine Guerquin, Jean-Charles Gaillard, Jean Armengaud, Francina Langa, Attila Toth, Emmanuelle Martini and Gabriel Livera ()
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Emilie Abby: Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Stem Cells and Radiation
Sophie Tourpin: Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Stem Cells and Radiation
Jonathan Ribeiro: Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Stem Cells and Radiation
Katrin Daniel: Molecular Cell Biology Group/Experimental Center, Institute of Physiological Chemistry, Medical School, MTZ, Dresden University of Technology
Sébastien Messiaen: Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Stem Cells and Radiation
Delphine Moison: Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Stem Cells and Radiation
Justine Guerquin: Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Stem Cells and Radiation
Jean-Charles Gaillard: CEA, DSV/IBITEC-S/SPI/Li2D, Laboratory ‘Innovative Technologies for Detection and Diagnostic’, CEA-Marcoule
Jean Armengaud: CEA, DSV/IBITEC-S/SPI/Li2D, Laboratory ‘Innovative Technologies for Detection and Diagnostic’, CEA-Marcoule
Francina Langa: Centre d'Ingénierie Génétique Murine, Institut Pasteur
Attila Toth: Molecular Cell Biology Group/Experimental Center, Institute of Physiological Chemistry, Medical School, MTZ, Dresden University of Technology
Emmanuelle Martini: Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Stem Cells and Radiation
Gabriel Livera: Université Paris Diderot, Sorbonne Paris Cité, Laboratory of Development of the Gonads, Unit of Stem Cells and Radiation

Nature Communications, 2016, vol. 7, issue 1, 1-16

Abstract: Abstract Sexual reproduction is crucially dependent on meiosis, a conserved, specialized cell division programme that is essential for the production of haploid gametes. Here we demonstrate that fertility and the implementation of the meiotic programme require a previously uncharacterized meiosis-specific protein, MEIOC. Meioc invalidation in mice induces early and pleiotropic meiotic defects in males and females. MEIOC prevents meiotic transcript degradation and interacts with an RNA helicase that binds numerous meiotic mRNAs. Our results indicate that proper engagement into meiosis necessitates the specific stabilization of meiotic transcripts, a previously little-appreciated feature in mammals. Remarkably, the upregulation of MEIOC at the onset of meiosis does not require retinoic acid and STRA8 signalling. Thus, we propose that the complete induction of the meiotic programme requires both retinoic acid-dependent and -independent mechanisms. The latter process involving post-transcriptional regulation likely represents an ancestral mechanism, given that MEIOC homologues are conserved throughout multicellular animals.

Date: 2016
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DOI: 10.1038/ncomms10324

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