Two-dimensional honeycomb network through sequence-controlled self-assembly of oligopeptides

Sabine Abb (), Ludger Harnau, Rico Gutzler, Stephan Rauschenbach () and Klaus Kern
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Sabine Abb: Max Planck Institute for Solid State Research
Rico Gutzler: Max Planck Institute for Solid State Research
Stephan Rauschenbach: Max Planck Institute for Solid State Research
Klaus Kern: Max Planck Institute for Solid State Research

Nature Communications, 2016, vol. 7, issue 1, 1-7

Abstract: Abstract The sequence of a peptide programs its self-assembly and hence the expression of specific properties through non-covalent interactions. A large variety of peptide nanostructures has been designed employing different aspects of these non-covalent interactions, such as dispersive interactions, hydrogen bonding or ionic interactions. Here we demonstrate the sequence-controlled fabrication of molecular nanostructures using peptides as bio-organic building blocks for two-dimensional (2D) self-assembly. Scanning tunnelling microscopy reveals changes from compact or linear assemblies (angiotensin I) to long-range ordered, chiral honeycomb networks (angiotensin II) as a result of removal of steric hindrance by sequence modification. Guided by our observations, molecular dynamic simulations yield atomistic models for the elucidation of interpeptide-binding motifs. This new approach to 2D self-assembly on surfaces grants insight at the atomic level that will enable the use of oligo- and polypeptides as large, multi-functional bio-organic building blocks, and opens a new route towards rationally designed, bio-inspired surfaces.

Date: 2016
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DOI: 10.1038/ncomms10335

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