In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics

Xiangzhao Ai, Chris Jun Hui Ho, Junxin Aw, Amalina Binte Ebrahim Attia, Jing Mu, Yu Wang, Xiaoyong Wang, Yong Wang, Xiaogang Liu, Huabing Chen, Mingyuan Gao, Xiaoyuan Chen, Edwin K.L. Yeow, Gang Liu (), Malini Olivo () and Bengang Xing ()
Additional contact information
Xiangzhao Ai: School of Physical and Mathematical Sciences, Nanyang Technological University
Chris Jun Hui Ho: Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR)
Junxin Aw: School of Physical and Mathematical Sciences, Nanyang Technological University
Amalina Binte Ebrahim Attia: Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR)
Jing Mu: School of Physical and Mathematical Sciences, Nanyang Technological University
Yu Wang: National University of Singapore
Xiaoyong Wang: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
Yong Wang: School of Radiation Medicine and Protection, Soochow University
Xiaogang Liu: National University of Singapore
Huabing Chen: School of Radiation Medicine and Protection, Soochow University
Mingyuan Gao: School of Radiation Medicine and Protection, Soochow University
Xiaoyuan Chen: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
Edwin K.L. Yeow: School of Physical and Mathematical Sciences, Nanyang Technological University
Gang Liu: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
Malini Olivo: Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR)
Bengang Xing: School of Physical and Mathematical Sciences, Nanyang Technological University

Nature Communications, 2016, vol. 7, issue 1, 1-9

Abstract: Abstract The development of precision nanomedicines to direct nanostructure-based reagents into tumour-targeted areas remains a critical challenge in clinics. Chemical reaction-mediated localization in response to tumour environmental perturbations offers promising opportunities for rational design of effective nano-theranostics. Here, we present a unique microenvironment-sensitive strategy for localization of peptide-premodified upconversion nanocrystals (UCNs) within tumour areas. Upon tumour-specific cathepsin protease reactions, the cleavage of peptides induces covalent cross-linking between the exposed cysteine and 2-cyanobenzothiazole on neighbouring particles, thus triggering the accumulation of UCNs into tumour site. Such enzyme-triggered cross-linking of UCNs leads to enhanced upconversion emission upon 808 nm laser irradiation, and in turn amplifies the singlet oxygen generation from the photosensitizers attached on UCNs. Importantly, this design enables remarkable tumour inhibition through either intratumoral UCNs injection or intravenous injection of nanoparticles modified with the targeting ligand. Our strategy may provide a multimodality solution for effective molecular sensing and site-specific tumour treatment.

Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (5)

Downloads: (external link)
https://www.nature.com/articles/ncomms10432 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10432

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms10432

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().