Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Minako Imamura, Atsushi Takahashi, Toshimasa Yamauchi, Kazuo Hara, Kazuki Yasuda, Niels Grarup, Wei Zhao, Xu Wang, Alicia Huerta-Chagoya, Cheng Hu, Sanghoon Moon, Jirong Long, Soo Heon Kwak, Asif Rasheed, Richa Saxena, Ronald C. W. Ma, Yukinori Okada, Minoru Iwata, Jun Hosoe, Nobuhiro Shojima, Minaka Iwasaki, Hayato Fujita, Ken Suzuki, John Danesh, Torben Jørgensen, Marit E. Jørgensen, Daniel R. Witte, Ivan Brandslund, Cramer Christensen, Torben Hansen, Josep M. Mercader, Jason Flannick, Hortensia Moreno-Macías, Noël P. Burtt, Rong Zhang, Young Jin Kim, Wei Zheng, Jai Rup Singh, Claudia H. T. Tam, Hiroshi Hirose, Hiroshi Maegawa, Chikako Ito, Kohei Kaku, Hirotaka Watada, Yasushi Tanaka, Kazuyuki Tobe, Ryuzo Kawamori, Michiaki Kubo, Yoon Shin Cho, Juliana C. N. Chan, Dharambir Sanghera, Philippe Frossard, Kyong Soo Park, Xiao-Ou Shu, Bong-Jo Kim, Jose C. Florez, Teresa Tusié-Luna, Weiping Jia, E Shyong Tai, Oluf Pedersen, Danish Saleheen, Shiro Maeda () and Takashi Kadowaki ()
Additional contact information
Minako Imamura: Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences
Atsushi Takahashi: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
Toshimasa Yamauchi: Graduate School of Medicine, University of Tokyo
Kazuo Hara: Graduate School of Medicine, University of Tokyo
Kazuki Yasuda: Diabetes Research Center, Research Institute, National Center for Global Health and Medicine
Niels Grarup: The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Wei Zhao: University of Pennsylvania
Xu Wang: Saw Swee Hock School of Public Health, National University of Singapore
Alicia Huerta-Chagoya: Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Cheng Hu: Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Sanghoon Moon: Center for Genome Science, National Institute of Health
Jirong Long: Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
Soo Heon Kwak: Seoul National University Hospital
Asif Rasheed: Center for Non-Communicable Diseases
Richa Saxena: Center for Human Genetic Research, Massachusetts General Hospital
Ronald C. W. Ma: The Chinese University of Hong Kong
Yukinori Okada: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
Minoru Iwata: University of Toyama
Jun Hosoe: Graduate School of Medicine, University of Tokyo
Nobuhiro Shojima: Graduate School of Medicine, University of Tokyo
Minaka Iwasaki: Graduate School of Medicine, University of Tokyo
Hayato Fujita: Graduate School of Medicine, University of Tokyo
Ken Suzuki: Graduate School of Medicine, University of Tokyo
John Danesh: University of Cambridge
Torben Jørgensen: Research Centre for Prevention and Health, Capital Region of Denmark
Marit E. Jørgensen: Steno Diabetes Center
Daniel R. Witte: Aarhus University
Ivan Brandslund: Lillebaelt Hospital
Cramer Christensen: Lillebaelt Hospital
Torben Hansen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Josep M. Mercader: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
Jason Flannick: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
Hortensia Moreno-Macías: Universidad Autónomas Metropolitana
Noël P. Burtt: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
Rong Zhang: Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Young Jin Kim: Center for Genome Science, National Institute of Health
Wei Zheng: Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
Jai Rup Singh: Central University of Punjab
Claudia H. T. Tam: The Chinese University of Hong Kong
Hiroshi Hirose: Health Center, Keio University
Hiroshi Maegawa: Shiga University of Medical Science
Chikako Ito: Grand Tower Medical Court Life Care Clinic
Kohei Kaku: Kawasaki Medical School
Hirotaka Watada: Juntendo University Graduate School of Medicine
Yasushi Tanaka: St Marianna University School of Medicine
Kazuyuki Tobe: University of Toyama
Ryuzo Kawamori: Sportology Center, Juntendo University Graduate School of Medicine
Michiaki Kubo: RIKEN Center for Integrative Medical Sciences
Yoon Shin Cho: Hallym University
Juliana C. N. Chan: The Chinese University of Hong Kong
Dharambir Sanghera: University of Oklahoma Health Sciences Center
Philippe Frossard: Center for Non-Communicable Diseases
Kyong Soo Park: Seoul National University Hospital
Xiao-Ou Shu: Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
Bong-Jo Kim: Center for Genome Science, National Institute of Health
Jose C. Florez: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
Teresa Tusié-Luna: Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Weiping Jia: Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
E Shyong Tai: Saw Swee Hock School of Public Health, National University of Singapore
Oluf Pedersen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
Danish Saleheen: University of Pennsylvania
Shiro Maeda: Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences
Takashi Kadowaki: Graduate School of Medicine, University of Tokyo

Nature Communications, 2016, vol. 7, issue 1, 1-12

Abstract: Abstract Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P

Date: 2016
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DOI: 10.1038/ncomms10531

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