Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum

Ake T. Lu, Eilis Hannon, Morgan E. Levine, Ke Hao, Eileen M. Crimmins, Katie Lunnon, Alexey Kozlenkov, Jonathan Mill, Stella Dracheva and Steve Horvath ()
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Ake T. Lu: David Geffen School of Medicine, University of California Los Angeles
Eilis Hannon: University of Exeter Medical School, University of Exeter
Morgan E. Levine: David Geffen School of Medicine, University of California Los Angeles
Ke Hao: The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Eileen M. Crimmins: Davis School of Gerontology, University of Southern California, Ethel Percy Andrus Gerontology Center
Katie Lunnon: University of Exeter Medical School, University of Exeter
Alexey Kozlenkov: Icahn School of Medicine at Mount Sinai
Jonathan Mill: University of Exeter Medical School, University of Exeter
Stella Dracheva: Icahn School of Medicine at Mount Sinai
Steve Horvath: David Geffen School of Medicine, University of California Los Angeles

Nature Communications, 2016, vol. 7, issue 1, 1-9

Abstract: Abstract DNA methylation (DNAm) levels lend themselves for defining an epigenetic biomarker of aging known as the ‘epigenetic clock’. Our genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identifies five significant (P

Date: 2016
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DOI: 10.1038/ncomms10561

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