Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation

Janet Berrios, Alice M. Stamatakis, Pranish A. Kantak, Zoe A. McElligott, Matthew C. Judson, Megumi Aita, Marie Rougie, Garret D. Stuber () and Benjamin D. Philpot ()
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Janet Berrios: Curriculum in Neurobiology, University of North Carolina
Alice M. Stamatakis: Curriculum in Neurobiology, University of North Carolina
Pranish A. Kantak: Neuroscience Center, University of North Carolina
Zoe A. McElligott: University of North Carolina
Matthew C. Judson: University of North Carolina
Megumi Aita: University of North Carolina
Marie Rougie: University of North Carolina
Garret D. Stuber: Curriculum in Neurobiology, University of North Carolina
Benjamin D. Philpot: Curriculum in Neurobiology, University of North Carolina

Nature Communications, 2016, vol. 7, issue 1, 1-8

Abstract: Abstract Motivated reward-seeking behaviours are governed by dopaminergic ventral tegmental area projections to the nucleus accumbens. In addition to dopamine, these mesoaccumbal terminals co-release other neurotransmitters including glutamate and GABA, whose roles in regulating motivated behaviours are currently being investigated. Here we demonstrate that loss of the E3-ubiquitin ligase, UBE3A, from tyrosine hydroxylase-expressing neurons impairs mesoaccumbal, non-canonical GABA co-release and enhances reward-seeking behaviour measured by optical self-stimulation.

Date: 2016
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DOI: 10.1038/ncomms10702

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