Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease

Dag Sehlin, Xiaotian T. Fang, Linda Cato, Gunnar Antoni, Lars Lannfelt and Stina Syvänen ()
Additional contact information
Dag Sehlin: Uppsala University, Rudbeck Laboratory
Xiaotian T. Fang: Uppsala University, Rudbeck Laboratory
Linda Cato: Uppsala University, Rudbeck Laboratory
Gunnar Antoni: Preclinical PET Platform, Uppsala University
Lars Lannfelt: Uppsala University, Rudbeck Laboratory
Stina Syvänen: Uppsala University, Rudbeck Laboratory

Nature Communications, 2016, vol. 7, issue 1, 1-11

Abstract: Abstract Owing to their specificity and high-affinity binding, monoclonal antibodies have potential as positron emission tomography (PET) radioligands and are currently used to image various targets in peripheral organs. However, in the central nervous system, antibody uptake is limited by the blood–brain barrier (BBB). Here we present a PET ligand to be used for diagnosis and evaluation of treatment effects in Alzheimer’s disease. The amyloid β (Aβ) antibody mAb158 is radiolabelled and conjugated to a transferrin receptor antibody to enable receptor-mediated transcytosis across the BBB. PET imaging of two different mouse models with Aβ pathology clearly visualize Aβ in the brain. The PET signal increases with age and correlates closely with brain Aβ levels. Thus, we demonstrate that antibody-based PET ligands can be successfully used for brain imaging.

Date: 2016
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms10759 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10759

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms10759

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().