Calcium imaging of sleep–wake related neuronal activity in the dorsal pons

Julia Cox, Lucas Pinto and Yang Dan ()
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Julia Cox: Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, 230 Li Ka Shing Center, Berkeley, California 94720, USA
Lucas Pinto: Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, 230 Li Ka Shing Center, Berkeley, California 94720, USA
Yang Dan: Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, 230 Li Ka Shing Center, Berkeley, California 94720, USA

Nature Communications, 2016, vol. 7, issue 1, 1-7

Abstract: Abstract The dorsal pons has long been implicated in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain poorly understood. Using cell-type-specific microendoscopic Ca2+ imaging in and near the laterodorsal tegmental nucleus, we found that many glutamatergic neurons are maximally active during REM sleep (REM-max), while the majority of GABAergic neurons are maximally active during wakefulness (wake-max). Furthermore, the activity of glutamatergic neurons exhibits a medio-lateral spatial gradient, with medially located neurons more selectively active during REM sleep.

Date: 2016
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DOI: 10.1038/ncomms10763

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