YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity

Soo Seok Hwang, Sung Woong Jang, Min Kyung Kim, Lark Kyun Kim, Bong-Sung Kim, Hyeong Su Kim, Kiwan Kim, Wonyong Lee, Richard A. Flavell and Gap Ryol Lee ()
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Soo Seok Hwang: Sogang University
Sung Woong Jang: Sogang University
Min Kyung Kim: Sogang University
Lark Kyun Kim: Yale University School of Medicine
Bong-Sung Kim: Yale University School of Medicine
Hyeong Su Kim: Sogang University
Kiwan Kim: Sogang University
Wonyong Lee: Sogang University
Richard A. Flavell: Yale University School of Medicine
Gap Ryol Lee: Sogang University

Nature Communications, 2016, vol. 7, issue 1, 1-15

Abstract: Abstract Regulatory T (Treg) cells are essential for maintenance of immune homeostasis. Foxp3 is the key transcription factor for Treg-cell differentiation and function; however, molecular mechanisms for its negative regulation are poorly understood. Here we show that YY1 expression is lower in Treg cells than Tconv cells, and its overexpression causes a marked reduction of Foxp3 expression and abrogation of suppressive function of Treg cells. YY1 is increased in Treg cells under inflammatory conditions with concomitant decrease of suppressor activity in dextran sulfate-induced colitis model. YY1 inhibits Smad3/4 binding to and chromatin remodelling of the Foxp3 locus. In addition, YY1 interrupts Foxp3-dependent target gene expression by physically interacting with Foxp3 and by directly binding to the Foxp3 target genes. Thus, YY1 inhibits differentiation and function of Treg cells by blocking Foxp3.

Date: 2016
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DOI: 10.1038/ncomms10789

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