Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules

Konrad Buscher (), Huiyu Wang, Xueli Zhang, Paul Striewski, Benedikt Wirth, Gurpanna Saggu, Stefan Lütke-Enking, Tanya N. Mayadas, Klaus Ley, Lydia Sorokin and Jian Song ()
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Konrad Buscher: Institute of Physiological Chemistry and Pathobiochemistry, University of Muenster
Huiyu Wang: Institute of Physiological Chemistry and Pathobiochemistry, University of Muenster
Xueli Zhang: Institute of Physiological Chemistry and Pathobiochemistry, University of Muenster
Paul Striewski: Cells-in-Motion Cluster of Excellence, University of Muenster
Benedikt Wirth: Cells-in-Motion Cluster of Excellence, University of Muenster
Gurpanna Saggu: Center for Excellence in Vascular Biology, Brigham and Women's Hospital and Harvard Medical School
Stefan Lütke-Enking: Institute of Physiological Chemistry and Pathobiochemistry, University of Muenster
Tanya N. Mayadas: Center for Excellence in Vascular Biology, Brigham and Women's Hospital and Harvard Medical School
Klaus Ley: La Jolla Institute for Allergy and Immunology
Lydia Sorokin: Institute of Physiological Chemistry and Pathobiochemistry, University of Muenster
Jian Song: Institute of Physiological Chemistry and Pathobiochemistry, University of Muenster

Nature Communications, 2016, vol. 7, issue 1, 1-7

Abstract: Abstract Acute peritonitis is a frequent medical condition that can trigger severe sepsis as a life-threatening complication. Neutrophils are first-responders in infection but recruitment mechanisms to the abdominal cavity remain poorly defined. Here, we demonstrate that high endothelial venules (HEVs) of the greater omentum constitute a main entry pathway in TNFα-, Escherichia coli (E. coli)- and caecal ligation and puncture-induced models of inflammation. Neutrophil transmigration across HEVs is faster than across conventional postcapillary venules and requires a unique set of adhesion receptors including peripheral node addressin, E-, L-selectin and Mac-1 but not P-selectin or LFA-1. Omental milky spots readily concentrate intra-abdominal E. coli where macrophages and recruited neutrophils collaborate in phagocytosis and killing. Inhibition of the omental neutrophil response exacerbates septic progression of peritonitis. This data identifies HEVs as a clinically relevant vascular recruitment site for neutrophils in acute peritonitis that is indispensable for host defence against early systemic bacterial spread and sepsis.

Date: 2016
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DOI: 10.1038/ncomms10828

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