Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells

Noelia Madroñal, José M. Delgado-García, Azahara Fernández-Guizán, Jayanta Chatterjee, Maja Köhn, Camilla Mattucci, Apar Jain, Theodoros Tsetsenis, Anna Illarionova, Valery Grinevich, Cornelius T. Gross () and Agnès Gruart
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Noelia Madroñal: Mouse Biology Unit, European Molecular Biology Laboratory (EMBL)
José M. Delgado-García: University Pablo Olavide
Azahara Fernández-Guizán: University Pablo Olavide
Jayanta Chatterjee: Genome Biology Unit, European Molecular Biology Laboratory (EMBL)
Maja Köhn: Genome Biology Unit, European Molecular Biology Laboratory (EMBL)
Camilla Mattucci: Mouse Biology Unit, European Molecular Biology Laboratory (EMBL)
Apar Jain: Mouse Biology Unit, European Molecular Biology Laboratory (EMBL)
Theodoros Tsetsenis: Mouse Biology Unit, European Molecular Biology Laboratory (EMBL)
Anna Illarionova: Schaller Research Group on Neuropeptides, German Cancer Research Center DKFZ, Central Institute of Mental Health, CellNetwork Cluster of Excellence, University of Heidelberg
Valery Grinevich: Schaller Research Group on Neuropeptides, German Cancer Research Center DKFZ, Central Institute of Mental Health, CellNetwork Cluster of Excellence, University of Heidelberg
Cornelius T. Gross: Mouse Biology Unit, European Molecular Biology Laboratory (EMBL)
Agnès Gruart: University Pablo Olavide

Nature Communications, 2016, vol. 7, issue 1, 1-10

Abstract: Abstract The hippocampus is critical for the acquisition and retrieval of episodic and contextual memories. Lesions of the dentate gyrus, a principal input of the hippocampus, block memory acquisition, but it remains unclear whether this region also plays a role in memory retrieval. Here we combine cell-type specific neural inhibition with electrophysiological measurements of learning-associated plasticity in behaving mice to demonstrate that dentate gyrus granule cells are not required for memory retrieval, but instead have an unexpected role in memory maintenance. Furthermore, we demonstrate the translational potential of our findings by showing that pharmacological activation of an endogenous inhibitory receptor expressed selectively in dentate gyrus granule cells can induce a rapid loss of hippocampal memory. These findings open a new avenue for the targeted erasure of episodic and contextual memories.

Date: 2016
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DOI: 10.1038/ncomms10923

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