Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer

Zhou Du, Tong Sun, Ezgi Hacisuleyman, Teng Fei, Xiaodong Wang, Myles Brown, John L. Rinn, Mary Gwo-Shu Lee, Yiwen Chen (), Philip W. Kantoff () and X. Shirley Liu ()
Additional contact information
Zhou Du: Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital
Tong Sun: Dana-Farber Cancer Institute
Ezgi Hacisuleyman: Harvard University
Teng Fei: Dana-Farber Cancer Institute
Xiaodong Wang: Dana-Farber Cancer Institute
Myles Brown: Dana-Farber Cancer Institute
John L. Rinn: Harvard University
Mary Gwo-Shu Lee: Dana-Farber Cancer Institute
Yiwen Chen: University of Texas MD Anderson Cancer Center
Philip W. Kantoff: Dana-Farber Cancer Institute
X. Shirley Liu: Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute

Nature Communications, 2016, vol. 7, issue 1, 1-10

Abstract: Abstract Mounting evidence suggests that long noncoding RNAs (lncRNAs) can function as microRNA sponges and compete for microRNA binding to protein-coding transcripts. However, the prevalence, functional significance and targets of lncRNA-mediated sponge regulation of cancer are mostly unknown. Here we identify a lncRNA-mediated sponge regulatory network that affects the expression of many protein-coding prostate cancer driver genes, by integrating analysis of sequence features and gene expression profiles of both lncRNAs and protein-coding genes in tumours. We confirm the tumour-suppressive function of two lncRNAs (TUG1 and CTB-89H12.4) and their regulation of PTEN expression in prostate cancer. Surprisingly, one of the two lncRNAs, TUG1, was previously known for its function in polycomb repressive complex 2 (PRC2)-mediated transcriptional regulation, suggesting its sub-cellular localization-dependent function. Our findings not only suggest an important role of lncRNA-mediated sponge regulation in cancer, but also underscore the critical influence of cytoplasmic localization on the efficacy of a sponge lncRNA.

Date: 2016
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms10982 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10982

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms10982

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().