Function and evolution of local repeats in the Firre locus

Ezgi Hacisuleyman, Chinmay J. Shukla, Catherine L. Weiner and John L. Rinn ()
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Ezgi Hacisuleyman: Harvard University
Chinmay J. Shukla: Harvard University
Catherine L. Weiner: Harvard University
John L. Rinn: Harvard University

Nature Communications, 2016, vol. 7, issue 1, 1-12

Abstract: Abstract More than half the human and mouse genomes are comprised of repetitive sequences, such as transposable elements (TEs), which have been implicated in many biological processes. In contrast, much less is known about other repeats, such as local repeats that occur in multiple instances within a given locus in the genome but not elsewhere. Here, we systematically characterize local repeats in the genomic locus of the Firre long noncoding RNA (lncRNA). We find a conserved function for the RRD repeat as a ribonucleic nuclear retention signal that is sufficient to retain an otherwise cytoplasmic mRNA in the nucleus. We also identified a repeat, termed R0, that can function as a DNA enhancer element within the intronic sequences of Firre. Collectively, our data suggest that local repeats can have diverse functionalities and molecular modalities in the Firre locus and perhaps more globally in other lncRNAs.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11021

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DOI: 10.1038/ncomms11021

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