Rotational manipulation of single cells and organisms using acoustic waves

Daniel Ahmed, Adem Ozcelik, Nagagireesh Bojanala, Nitesh Nama, Awani Upadhyay, Yuchao Chen, Wendy Hanna-Rose and Tony Jun Huang ()
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Daniel Ahmed: The Pennsylvania State University
Adem Ozcelik: The Pennsylvania State University
Nagagireesh Bojanala: The Pennsylvania State University
Nitesh Nama: The Pennsylvania State University
Awani Upadhyay: The Pennsylvania State University
Yuchao Chen: The Pennsylvania State University
Wendy Hanna-Rose: The Pennsylvania State University
Tony Jun Huang: The Pennsylvania State University

Nature Communications, 2016, vol. 7, issue 1, 1-11

Abstract: Abstract The precise rotational manipulation of single cells or organisms is invaluable to many applications in biology, chemistry, physics and medicine. In this article, we describe an acoustic-based, on-chip manipulation method that can rotate single microparticles, cells and organisms. To achieve this, we trapped microbubbles within predefined sidewall microcavities inside a microchannel. In an acoustic field, trapped microbubbles were driven into oscillatory motion generating steady microvortices which were utilized to precisely rotate colloids, cells and entire organisms (that is, C. elegans). We have tested the capabilities of our method by analysing reproductive system pathologies and nervous system morphology in C. elegans. Using our device, we revealed the underlying abnormal cell fusion causing defective vulval morphology in mutant worms. Our acoustofluidic rotational manipulation (ARM) technique is an easy-to-use, compact, and biocompatible method, permitting rotation regardless of optical, magnetic or electrical properties of the sample under investigation.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11085

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DOI: 10.1038/ncomms11085

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