Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling

Jose Maria Carvajal-Gonzalez (), Angel-Carlos Roman and Marek Mlodzik ()
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Jose Maria Carvajal-Gonzalez: Tisch Cancer Institute, and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
Angel-Carlos Roman: Champalimaud Neuroscience Programme
Marek Mlodzik: Tisch Cancer Institute, and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai

Nature Communications, 2016, vol. 7, issue 1, 1-9

Abstract: Abstract Planar cell polarity (PCP) signalling is a well-conserved developmental pathway regulating cellular orientation during development. An evolutionarily conserved pathway readout is not established and, moreover, it is thought that PCP mediated cellular responses are tissue-specific. A key PCP function in vertebrates is to regulate coordinated centriole/cilia positioning, a function that has not been associated with PCP in Drosophila. Here we report instructive input of Frizzled-PCP (Fz/PCP) signalling into polarized centriole positioning in Drosophila wings. We show that centrioles are polarized in pupal wing cells as a readout of PCP signalling, with both gain and loss-of-function Fz/PCP signalling affecting centriole polarization. Importantly, loss or gain of centrioles does not affect Fz/PCP establishment, implicating centriolar positioning as a conserved PCP-readout, likely downstream of PCP-regulated actin polymerization. Together with vertebrate data, these results suggest a unifying model of centriole/cilia positioning as a common downstream effect of PCP signalling from flies to mammals.

Date: 2016
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DOI: 10.1038/ncomms11135

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