ASK1 signalling regulates brown and beige adipocyte function

Kazuki Hattori, Isao Naguro, Kohki Okabe, Takashi Funatsu, Shotaro Furutani, Kohsuke Takeda and Hidenori Ichijo ()
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Kazuki Hattori: The laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Isao Naguro: The laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Kohki Okabe: The laboratory of Bioanalytical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Takashi Funatsu: The laboratory of Bioanalytical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Shotaro Furutani: The laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Kohsuke Takeda: Graduate School of Biomedical Sciences, Nagasaki University
Hidenori Ichijo: The laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo

Nature Communications, 2016, vol. 7, issue 1, 1-10

Abstract: Abstract Recent studies suggest that adult humans have active brown or beige adipocytes, the activation of which might be a therapeutic strategy for the treatment of diverse metabolic diseases. Here we show that the protein kinase ASK1 regulates brown and beige adipocytes function. In brown or white adipocytes, the PKA-ASK1-p38 axis is activated in response to cAMP signalling and contributes to the cell-autonomous induction of genes, including Ucp1. Global and fat-specific ASK1 deficiency leads to impaired metabolic responses, including thermogenesis and oxygen consumption, at the cell and whole-body levels, respectively. Our data thus indicate that the ASK1 signalling axis is a regulator of brown and beige adipocyte gene expression and function.

Date: 2016
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DOI: 10.1038/ncomms11158

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