FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth

Felipe Slebe, Federico Rojo, Maria Vinaixa, Mar García-Rocha, Giorgia Testoni, Marc Guiu, Evarist Planet, Sara Samino, Enrique J. Arenas, Antoni Beltran, Ana Rovira, Ana Lluch, Xavier Salvatella, Oscar Yanes, Joan Albanell, Joan J. Guinovart () and Roger R. Gomis ()
Additional contact information
Felipe Slebe: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Federico Rojo: Cancer Research Programme, IMIM (Hospital del Mar Medical Research Institute)
Maria Vinaixa: Centre for Omic Sciences, Universitat Rovira i Virgili
Mar García-Rocha: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Giorgia Testoni: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Marc Guiu: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Evarist Planet: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Sara Samino: Centre for Omic Sciences, Universitat Rovira i Virgili
Enrique J. Arenas: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Antoni Beltran: Centre for Omic Sciences, Universitat Rovira i Virgili
Ana Rovira: Cancer Research Programme, IMIM (Hospital del Mar Medical Research Institute)
Ana Lluch: Medical Oncology Service, Hospital Clinico
Xavier Salvatella: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Oscar Yanes: Centre for Omic Sciences, Universitat Rovira i Virgili
Joan Albanell: Cancer Research Programme, IMIM (Hospital del Mar Medical Research Institute)
Joan J. Guinovart: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Roger R. Gomis: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology

Nature Communications, 2016, vol. 7, issue 1, 1-11

Abstract: Abstract The mechanisms that allow breast cancer (BCa) cells to metabolically sustain rapid growth are poorly understood. Here we report that BCa cells are dependent on a mechanism to supply precursors for intracellular lipid production derived from extracellular sources and that the endothelial lipase (LIPG) fulfils this function. LIPG expression allows the import of lipid precursors, thereby contributing to BCa proliferation. LIPG stands out as an essential component of the lipid metabolic adaptations that BCa cells, and not normal tissue, must undergo to support high proliferation rates. LIPG is ubiquitously and highly expressed under the control of FoxA1 or FoxA2 in all BCa subtypes. The downregulation of either LIPG or FoxA in transformed cells results in decreased proliferation and impaired synthesis of intracellular lipids.

Date: 2016
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DOI: 10.1038/ncomms11199

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