miRNA863-3p sequentially targets negative immune regulator ARLPKs and positive regulator SERRATE upon bacterial infection

Dongdong Niu, Yifan E. Lii, Padmanabhan Chellappan, Lei Lei, Karl Peralta, Chunhao Jiang, Jianhua Guo, Gitta Coaker and Hailing Jin ()
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Dongdong Niu: Nanjing Agriculture University
Yifan E. Lii: Center for Plant Cell Biology and Institute for Integrative Genome Biology, University of California
Padmanabhan Chellappan: Center for Plant Cell Biology and Institute for Integrative Genome Biology, University of California
Lei Lei: University of California
Karl Peralta: Center for Plant Cell Biology and Institute for Integrative Genome Biology, University of California
Chunhao Jiang: Nanjing Agriculture University
Jianhua Guo: Nanjing Agriculture University
Gitta Coaker: University of California
Hailing Jin: Center for Plant Cell Biology and Institute for Integrative Genome Biology, University of California

Nature Communications, 2016, vol. 7, issue 1, 1-13

Abstract: Abstract Plant small RNAs play important roles in gene regulation during pathogen infection. Here we show that miR863-3p is induced by the bacterial pathogen Pseudomonas syringae carrying various effectors. Early during infection, miR863-3p silences two negative regulators of plant defence, atypical receptor-like pseudokinase1 (ARLPK1) and ARLPK2, both lacking extracellular domains and kinase activity, through mRNA degradation to promote immunity. ARLPK1 associates with, and may function through another negative immune regulator ARLPK1-interacting receptor-like kinase 1 (AKIK1), an active kinase with an extracellular domain. Later during infection, miR863-3p silences SERRATE, which is essential for miRNA accumulation and positively regulates defence, through translational inhibition. This results in decreased miR863-3p levels, thus forming a negative feedback loop to attenuate immune responses after successful defence. This is an example of a miRNA that sequentially targets both negative and positive regulators of immunity through two modes of action to fine-tune the timing and amplitude of defence responses.

Date: 2016
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DOI: 10.1038/ncomms11324

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