Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism

Yuefeng Tang, Martina Wallace, Joan Sanchez-Gurmaches, Wen-Yu Hsiao, Huawei Li, Peter L. Lee, Santiago Vernia, Christian M. Metallo and David A. Guertin ()
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Yuefeng Tang: Program in Molecular Medicine, University of Massachusetts Medical School
Martina Wallace: University of California, San Diego
Joan Sanchez-Gurmaches: Program in Molecular Medicine, University of Massachusetts Medical School
Wen-Yu Hsiao: Program in Molecular Medicine, University of Massachusetts Medical School
Huawei Li: Program in Molecular Medicine, University of Massachusetts Medical School
Peter L. Lee: Program in Molecular Medicine, University of Massachusetts Medical School
Santiago Vernia: Program in Molecular Medicine, University of Massachusetts Medical School
Christian M. Metallo: University of California, San Diego
David A. Guertin: Program in Molecular Medicine, University of Massachusetts Medical School

Nature Communications, 2016, vol. 7, issue 1, 1-14

Abstract: Abstract Adipose tissue de novo lipogenesis (DNL) positively influences insulin sensitivity, is reduced in obesity, and predicts insulin resistance. Therefore, elucidating mechanisms controlling adipose tissue DNL could lead to therapies for type 2 diabetes. Here, we report that mechanistic target of rapamycin complex 2 (mTORC2) functions in white adipose tissue (WAT) to control expression of the lipogenic transcription factor ChREBPβ. Conditionally deleting the essential mTORC2 subunit Rictor in mature adipocytes decreases ChREBPβ expression, which reduces DNL in WAT, and impairs hepatic insulin sensitivity. Mechanistically, Rictor/mTORC2 promotes ChREBPβ expression in part by controlling glucose uptake, but without impairing pan-AKT signalling. High-fat diet also rapidly decreases adipose tissue ChREBPβ expression and insulin sensitivity in wild-type mice, and does not further exacerbate insulin resistance in adipose tissue Rictor knockout mice, implicating adipose tissue DNL as an early target in diet-induced insulin resistance. These data suggest mTORC2 functions in WAT as part of an extra-hepatic nutrient-sensing mechanism to control glucose homeostasis.

Date: 2016
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DOI: 10.1038/ncomms11365

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