Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation

Nicholas Collins, Xiaodong Jiang, Ali Zaid, Bethany L. Macleod, Jane Li, Chang Ook Park, Ashraful Haque, Sammy Bedoui, William R. Heath, Scott N. Mueller, Thomas S. Kupper, Thomas Gebhardt () and Francis R. Carbone ()
Additional contact information
Nicholas Collins: The University of Melbourne
Xiaodong Jiang: Brigham and Women’s Hospital, Harvard Medical School
Ali Zaid: The University of Melbourne
Bethany L. Macleod: The University of Melbourne
Jane Li: The University of Melbourne
Chang Ook Park: Brigham and Women’s Hospital, Harvard Medical School
Ashraful Haque: Malaria Immunology Laboratory, QIMR Berghofer Medical Research Institute and Australian Infectious Diseases Research Centre, The University of Queensland
Sammy Bedoui: The University of Melbourne
William R. Heath: The University of Melbourne
Scott N. Mueller: The University of Melbourne
Thomas S. Kupper: Brigham and Women’s Hospital, Harvard Medical School
Thomas Gebhardt: The University of Melbourne
Francis R. Carbone: The University of Melbourne

Nature Communications, 2016, vol. 7, issue 1, 1-13

Abstract: Abstract Although memory T cells within barrier tissues can persist as permanent residents, at least some exchange with blood. The extent to which this occurs is unclear. Here we show that memory CD4+ T cells in mouse skin are in equilibrium with the circulation at steady state. These cells are dispersed throughout the inter-follicular regions of the dermis and form clusters with antigen presenting cells around hair follicles. After infection or administration of a contact sensitizing agent, there is a sustained increase in skin CD4+ T-cell content, which is confined to the clusters, with a concomitant CCL5-dependent increase in CD4+ T-cell recruitment. Skin CCL5 is derived from CD11b+ cells and CD8+ T cells, with the elimination of the latter decreasing CD4+ T-cell numbers. These results reveal a complex pattern of tissue-retention and equilibration for CD4+ memory T cells in skin, which is altered by infection and inflammation history.

Date: 2016
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms11514 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11514

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms11514

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().