The dynamic transcriptional and translational landscape of the model antibiotic producer Streptomyces coelicolor A3(2)

Yujin Jeong, Ji-Nu Kim, Min Woo Kim, Giselda Bucca, Suhyung Cho, Yeo Joon Yoon, Byung-Gee Kim, Jung-Hye Roe, Sun Chang Kim, Colin P. Smith and Byung-Kwan Cho ()
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Yujin Jeong: Korea Advanced Institute of Science and Technology
Ji-Nu Kim: School of Chemical and Biological Engineering, Seoul National University
Min Woo Kim: School of Chemical and Biological Engineering, Seoul National University
Giselda Bucca: Faculty of Health and Medical Sciences, University of Surrey
Suhyung Cho: Korea Advanced Institute of Science and Technology
Yeo Joon Yoon: Ewha Womans University
Byung-Gee Kim: School of Chemical and Biological Engineering, Seoul National University
Jung-Hye Roe: School of Biological Sciences, Seoul National University
Sun Chang Kim: Korea Advanced Institute of Science and Technology
Colin P. Smith: Faculty of Health and Medical Sciences, University of Surrey
Byung-Kwan Cho: Korea Advanced Institute of Science and Technology

Nature Communications, 2016, vol. 7, issue 1, 1-11

Abstract: Abstract Individual Streptomyces species have the genetic potential to produce a diverse array of natural products of commercial, medical and veterinary interest. However, these products are often not detectable under laboratory culture conditions. To harness their full biosynthetic potential, it is important to develop a detailed understanding of the regulatory networks that orchestrate their metabolism. Here we integrate nucleotide resolution genome-scale measurements of the transcriptome and translatome of Streptomyces coelicolor, the model antibiotic-producing actinomycete. Our systematic study determines 3,570 transcription start sites and identifies 230 small RNAs and a considerable proportion (∼21%) of leaderless mRNAs; this enables deduction of genome-wide promoter architecture. Ribosome profiling reveals that the translation efficiency of secondary metabolic genes is negatively correlated with transcription and that several key antibiotic regulatory genes are translationally induced at transition growth phase. These findings might facilitate the design of new approaches to antibiotic discovery and development.

Date: 2016
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DOI: 10.1038/ncomms11605

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