Identification of proliferative progenitors associated with prominent postnatal growth of the pons

Robert A. Lindquist, Cristina D. Guinto, Jose L. Rodas-Rodriguez, Luis C. Fuentealba, Matthew C. Tate, David H. Rowitch and Arturo Alvarez-Buylla ()
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Robert A. Lindquist: Eli & Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California—San Francisco
Cristina D. Guinto: Eli & Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California—San Francisco
Jose L. Rodas-Rodriguez: Eli & Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California—San Francisco
Luis C. Fuentealba: Eli & Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California—San Francisco
Matthew C. Tate: Eli & Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California—San Francisco
David H. Rowitch: Eli & Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California—San Francisco
Arturo Alvarez-Buylla: Eli & Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California—San Francisco

Nature Communications, 2016, vol. 7, issue 1, 1-16

Abstract: Abstract The pons controls crucial sensorimotor and autonomic functions. In humans, it grows sixfold postnatally and is a site of paediatric gliomas; however, the mechanisms of pontine growth remain poorly understood. We show that the murine pons quadruples in volume postnatally; growth is fastest during postnatal days 0–4 (P0–P4), preceding most myelination. We identify three postnatal proliferative compartments: ventricular, midline and parenchymal. We find no evidence of postnatal neurogenesis in the pons, but each progenitor compartment produces new astroglia and oligodendroglia; the latter expand 10- to 18-fold postnatally, and are derived mostly from the parenchyma. Nearly all parenchymal progenitors at P4 are Sox2+Olig2+, but by P8 a Sox2− subpopulation emerges, suggesting a lineage progression from Sox2+ ‘early’ to Sox2− ‘late’ oligodendrocyte progenitor. Fate mapping reveals that >90% of adult oligodendrocytes derive from P2–P3 Sox2+ progenitors. These results demonstrate the importance of postnatal Sox2+Olig2+ progenitors in pontine growth and oligodendrogenesis.

Date: 2016
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DOI: 10.1038/ncomms11628

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