A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins

Maofeng Jing, Baodian Guo, Haiyang Li, Bo Yang, Haonan Wang, Guanghui Kong, Yao Zhao, Huawei Xu, Yan Wang, Wenwu Ye, Suomeng Dong, Yongli Qiao, Brett M. Tyler, Wenbo Ma and Yuanchao Wang ()
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Maofeng Jing: Nanjing Agricultural University
Baodian Guo: Nanjing Agricultural University
Haiyang Li: Nanjing Agricultural University
Bo Yang: Nanjing Agricultural University
Haonan Wang: Nanjing Agricultural University
Guanghui Kong: Nanjing Agricultural University
Yao Zhao: Nanjing Agricultural University
Huawei Xu: Nanjing Agricultural University
Yan Wang: Nanjing Agricultural University
Wenwu Ye: Nanjing Agricultural University
Suomeng Dong: Nanjing Agricultural University
Yongli Qiao: Institute of Crop Science, Chinese Academy of Agricultural Sciences
Brett M. Tyler: Oregon State University
Wenbo Ma: University of California
Yuanchao Wang: Nanjing Agricultural University

Nature Communications, 2016, vol. 7, issue 1, 1-17

Abstract: Abstract Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector PsAvh262 to stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin proteins (BiPs), which act as negative regulators of plant resistance to Phytophthora. By stabilizing BiPs, PsAvh262 suppresses ER stress-triggered cell death and facilitates Phytophthora infection. The direct targeting of ER stress regulators may represent a common mechanism of host manipulation by microbes.

Date: 2016
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DOI: 10.1038/ncomms11685

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