Simultaneous optical and electrical in vivo analysis of the enteric nervous system

Nikolai Rakhilin, Bradley Barth, Jiahn Choi, Nini L. Muñoz, Subhash Kulkarni, Jason S. Jones, David M. Small, Yu-Ting Cheng, Yingqiu Cao, Colleen LaVinka, Edwin Kan, Xinzhong Dong, Michael Spencer, Pankaj Pasricha, Nozomi Nishimura () and Xiling Shen ()
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Nikolai Rakhilin: School of Electrical and Computer Engineering, Cornell University
Bradley Barth: Cornell University
Jiahn Choi: Cornell University
Nini L. Muñoz: School of Electrical and Computer Engineering, Cornell University
Subhash Kulkarni: Center for Neurogastroenterology, Johns Hopkins University
Jason S. Jones: Cornell University
David M. Small: Cornell University
Yu-Ting Cheng: Cornell University
Yingqiu Cao: School of Electrical and Computer Engineering, Cornell University
Colleen LaVinka: Center for Sensory Biology, Johns Hopkins University School of Medicine
Edwin Kan: School of Electrical and Computer Engineering, Cornell University
Xinzhong Dong: Center for Sensory Biology, Johns Hopkins University School of Medicine
Michael Spencer: School of Electrical and Computer Engineering, Cornell University
Pankaj Pasricha: Center for Neurogastroenterology, Johns Hopkins University
Nozomi Nishimura: Cornell University
Xiling Shen: School of Electrical and Computer Engineering, Cornell University

Nature Communications, 2016, vol. 7, issue 1, 1-7

Abstract: Abstract The enteric nervous system (ENS) is a major division of the nervous system and vital to the gastrointestinal (GI) tract and its communication with the rest of the body. Unlike the brain and spinal cord, relatively little is known about the ENS in part because of the inability to directly monitor its activity in live animals. Here, we integrate a transparent graphene sensor with a customized abdominal window for simultaneous optical and electrical recording of the ENS in vivo. The implanted device captures ENS responses to neurotransmitters, drugs and optogenetic manipulation in real time.

Date: 2016
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DOI: 10.1038/ncomms11800

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