Circadian regulation of human cortical excitability

Julien Q. M. Ly, Giulia Gaggioni, Sarah L. Chellappa, Soterios Papachilleos, Alexandre Brzozowski, Chloé Borsu, Mario Rosanova, Simone Sarasso, Benita Middleton, André Luxen, Simon N. Archer, Christophe Phillips, Derk-Jan Dijk, Pierre Maquet, Marcello Massimini and Gilles Vandewalle ()
Additional contact information
Julien Q. M. Ly: GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
Giulia Gaggioni: GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
Sarah L. Chellappa: GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
Soterios Papachilleos: GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
Alexandre Brzozowski: GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
Chloé Borsu: GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
Mario Rosanova: Universit degli Studi di Milano
Simone Sarasso: Universit degli Studi di Milano
Benita Middleton: Surrey Sleep Research Centre, University of Surrey
André Luxen: GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
Simon N. Archer: Surrey Sleep Research Centre, University of Surrey
Christophe Phillips: GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
Derk-Jan Dijk: Surrey Sleep Research Centre, University of Surrey
Pierre Maquet: GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège
Marcello Massimini: Universit degli Studi di Milano
Gilles Vandewalle: GIGA-Research, Cyclotron Research Centre–In Vivo Imaging Unit, University of Liège

Nature Communications, 2016, vol. 7, issue 1, 1-10

Abstract: Abstract Prolonged wakefulness alters cortical excitability, which is essential for proper brain function and cognition. However, besides prior wakefulness, brain function and cognition are also affected by circadian rhythmicity. Whether the regulation of cognition involves a circadian impact on cortical excitability is unknown. Here, we assessed cortical excitability from scalp electroencephalography (EEG) responses to transcranial magnetic stimulation in 22 participants during 29 h of wakefulness under constant conditions. Data reveal robust circadian dynamics of cortical excitability that are strongest in those individuals with highest endocrine markers of circadian amplitude. In addition, the time course of cortical excitability correlates with changes in EEG synchronization and cognitive performance. These results demonstrate that the crucial factor for cortical excitability, and basic brain function in general, is the balance between circadian rhythmicity and sleep need, rather than sleep homoeostasis alone. These findings have implications for clinical applications such as non-invasive brain stimulation in neurorehabilitation.

Date: 2016
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms11828 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11828

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms11828

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().