Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD

Wei Lin, Jing Zhang, Haiyan Lin, Zexing Li, Xiaofeng Sun, Di Xin, Meng Yang, Liwei Sun, Lin Li, Hongmei Wang, Dahua Chen () and Qinmiao Sun ()
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Wei Lin: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
Jing Zhang: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
Haiyan Lin: State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Zexing Li: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
Xiaofeng Sun: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
Di Xin: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
Meng Yang: State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Liwei Sun: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
Lin Li: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
Hongmei Wang: State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Dahua Chen: State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Qinmiao Sun: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences

Nature Communications, 2016, vol. 7, issue 1, 1-15

Abstract: Abstract Retinoic acid-inducible gene I (RIG-I) plays important roles in pathogen recognition and antiviral signalling transduction. Here we show that syndecan-4 (SDC4) is a RIG-I-interacting partner identified in a yeast two-hybrid screen. We find that SDC4 negatively regulates the RIG-I-mediated antiviral signalling in a feedback-loop control manner. The genetic evidence obtained by using knockout mice further emphasizes this biological role of SDC4 in antiviral signalling. Mechanistically, we show that SDC4 interacts with both RIG-I and deubiquitinase CYLD via its carboxyl-terminal intracellular region. SDC4 likely promotes redistribution of RIG-I and CYLD in a perinuclear pattern post viral infection, and thus enhances the RIG-I–CYLD interaction and potentiates the K63-linked deubiquitination of RIG-I. Collectively, our findings uncover a mechanism by which SDC4 antagonizes the activation of RIG-I in a CYLD-mediated deubiquitination-dependent process, thereby balancing antiviral signalling to avoid deleterious effects on host cells.

Date: 2016
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DOI: 10.1038/ncomms11848

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