DELLA-mediated PIF degradation contributes to coordination of light and gibberellin signalling in Arabidopsis

Kunlun Li, Renbo Yu, Liu-Min Fan, Ning Wei, Haodong Chen () and Xing Wang Deng ()
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Kunlun Li: State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, School of Advanced Agriculture Sciences, and School of Life Sciences, Peking University
Renbo Yu: State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, School of Advanced Agriculture Sciences, and School of Life Sciences, Peking University
Liu-Min Fan: State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, School of Advanced Agriculture Sciences, and School of Life Sciences, Peking University
Ning Wei: Cellular and Developmental Biology, Yale University
Haodong Chen: State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, School of Advanced Agriculture Sciences, and School of Life Sciences, Peking University
Xing Wang Deng: State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, School of Advanced Agriculture Sciences, and School of Life Sciences, Peking University

Nature Communications, 2016, vol. 7, issue 1, 1-11

Abstract: Abstract Light and gibberellins (GAs) antagonistically regulate hypocotyl elongation in plants. It has been demonstrated that DELLAs, which are negative regulators of GA signalling, inhibit phytochrome-interacting factors 3 and 4 (PIF3 and PIF4) by sequestering their DNA-recognition domains. However, it is unclear whether there are other mechanisms of regulatory crosstalk between DELLAs and PIFs. Here, we demonstrate that DELLAs negatively regulate the abundance of four PIF proteins through the ubiquitin–proteasome system. Reduction of PIF3 protein abundance by DELLAs correlates closely with reduced hypocotyl elongation. Both sequestration and degradation of PIF3 by DELLAs contribute to a reduction in PIF3 binding to its target genes. Thus, we show that promotion of PIF degradation by DELLAs is required to coordinate light and GA signals, and the dual regulation of transcription factors by DELLAs by both sequestration and degradation may be a general mechanism.

Date: 2016
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DOI: 10.1038/ncomms11868

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