TRPC5 channels participate in pressure-sensing in aortic baroreceptors

On-Chai Lau, Bing Shen, Ching-On Wong, Yung-Wui Tjong, Chun-Yin Lo, Hui-Chuan Wang, Yu Huang, Wing-Ho Yung, Yang-Chao Chen, Man-Lung Fung, John Anthony Rudd and Xiaoqiang Yao ()
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On-Chai Lau: Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong
Bing Shen: Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong
Ching-On Wong: Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong
Yung-Wui Tjong: Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong
Chun-Yin Lo: Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong
Hui-Chuan Wang: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong
Yu Huang: Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong
Wing-Ho Yung: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong
Yang-Chao Chen: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong
Man-Lung Fung: University of Hong Kong
John Anthony Rudd: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong
Xiaoqiang Yao: Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong

Nature Communications, 2016, vol. 7, issue 1, 1-12

Abstract: Abstract Blood pressure is maintained within a normal physiological range by a sophisticated regulatory mechanism. Baroreceptors serve as a frontline sensor to detect the change in blood pressure. Nerve signals are then sent to the cardiovascular control centre in the brain in order to stimulate baroreflex responses. Here, we identify TRPC5 channels as a mechanical sensor in aortic baroreceptors. In Trpc5 knockout mice, the pressure-induced action potential firings in the afferent nerve and the baroreflex-mediated heart rate reduction are attenuated. Telemetric measurements of blood pressure demonstrate that Trpc5 knockout mice display severe daily blood pressure fluctuation. Our results suggest that TRPC5 channels represent a key pressure transducer in the baroreceptors and play an important role in maintaining blood pressure stability. Because baroreceptor dysfunction contributes to a variety of cardiovascular diseases including hypertension, heart failure and myocardial infarction, our findings may have important future clinical implications.

Date: 2016
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DOI: 10.1038/ncomms11947

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