Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma

Harvind S. Chahal, Yuan Lin, Katherine J. Ransohoff, David A. Hinds, Wenting Wu, Hong-Ji Dai, Abrar A. Qureshi, Wen-Qing Li, Peter Kraft, Jean Y. Tang, Jiali Han () and Kavita Y. Sarin ()
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Harvind S. Chahal: Stanford University School of Medicine
Yuan Lin: Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
Katherine J. Ransohoff: Stanford University School of Medicine
David A. Hinds: 23andMe Inc.
Wenting Wu: Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
Hong-Ji Dai: Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
Abrar A. Qureshi: Warren Alpert Medical School, Brown University
Wen-Qing Li: Warren Alpert Medical School, Brown University
Peter Kraft: Harvard T.H. Chan School of Public Health
Jean Y. Tang: Stanford University School of Medicine
Jiali Han: Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
Kavita Y. Sarin: Stanford University School of Medicine

Nature Communications, 2016, vol. 7, issue 1, 1-8

Abstract: Abstract Cutaneous squamous cell carcinoma represents the second most common cutaneous malignancy, affecting 7–11% of Caucasians in the United States. The genetic determinants of susceptibility to cutaneous squamous cell carcinoma remain largely unknown. Here we report the results of a two-stage genome-wide association study of cutaneous squamous cell carcinoma, totalling 7,404 cases and 292,076 controls. Eleven loci reached genome-wide significance (P

Date: 2016
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DOI: 10.1038/ncomms12048

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