Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states

Antony Adamson, Christopher Boddington, Polly Downton, William Rowe, James Bagnall, Connie Lam, Apolinar Maya-Mendoza, Lorraine Schmidt, Claire V. Harper, David G. Spiller, David A. Rand, Dean A. Jackson (), Michael R. H. White () and Pawel Paszek ()
Additional contact information
Antony Adamson: Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester
Christopher Boddington: Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester
Polly Downton: Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester
William Rowe: Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester
James Bagnall: Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester
Connie Lam: Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester
Apolinar Maya-Mendoza: The Danish Cancer Society Research Center
Lorraine Schmidt: Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester
Claire V. Harper: Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester
David G. Spiller: Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester
David A. Rand: Warwick Systems Biology and Mathematics Institute, University of Warwick
Dean A. Jackson: Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester
Michael R. H. White: Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester
Pawel Paszek: Systems Microscopy Centre, Faculty of Life Sciences, University of Manchester

Nature Communications, 2016, vol. 7, issue 1, 1-14

Abstract: Abstract Cells respond dynamically to pulsatile cytokine stimulation. Here we report that single, or well-spaced pulses of TNFα (>100 min apart) give a high probability of NF-κB activation. However, fewer cells respond to shorter pulse intervals (

Date: 2016
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DOI: 10.1038/ncomms12057

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