miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy

Shawn S. Badal, Yin Wang, Jianyin Long, David L. Corcoran, Benny H. Chang, Luan D. Truong, Yashpal S. Kanwar, Paul A. Overbeek and Farhad R. Danesh ()
Additional contact information
Shawn S. Badal: Section of Nephrology, The University of Texas MD Anderson Cancer Center
Yin Wang: Section of Nephrology, The University of Texas MD Anderson Cancer Center
Jianyin Long: Section of Nephrology, The University of Texas MD Anderson Cancer Center
David L. Corcoran: Center for Genomic and Computational Biology, Duke University
Benny H. Chang: Baylor College of Medicine
Luan D. Truong: Houston Methodist Hospital
Yashpal S. Kanwar: Feinberg School of Medicine, Northwestern University
Paul A. Overbeek: Baylor College of Medicine
Farhad R. Danesh: Section of Nephrology, The University of Texas MD Anderson Cancer Center

Nature Communications, 2016, vol. 7, issue 1, 1-15

Abstract: Abstract How the kidney responds to the metabolic cues from the environment remains a central question in kidney research. This question is particularly relevant to the pathogenesis of diabetic nephropathy (DN) in which evidence suggests that metabolic events in podocytes regulate chromatin structure. Here, we show that miR-93 is a critical metabolic/epigenetic switch in the diabetic milieu linking the metabolic state to chromatin remodelling. Mice with inducible overexpression of a miR-93 transgene exclusively in podocytes exhibit significant improvements in key features of DN. We identify miR-93 as a regulator of nucleosomal dynamics in podocytes. miR-93 has a critical role in chromatin reorganization and progression of DN by modulating its target Msk2, a histone kinase, and its substrate H3S10. These findings implicate a central role for miR-93 in high glucose-induced chromatin remodelling in the kidney, and provide evidence for a previously unrecognized role for Msk2 as a target for DN therapy.

Date: 2016
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms12076 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12076

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms12076

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().