Eigenspectra optoacoustic tomography achieves quantitative blood oxygenation imaging deep in tissues

Stratis Tzoumas, Antonio Nunes, Ivan Olefir, Stefan Stangl, Panagiotis Symvoulidis, Sarah Glasl, Christine Bayer, Gabriele Multhoff and Vasilis Ntziachristos ()
Additional contact information
Stratis Tzoumas: Institute of Biological and Medical Imaging (IBMI), Helmholtz Zentrum München
Antonio Nunes: Institute of Biological and Medical Imaging (IBMI), Helmholtz Zentrum München
Ivan Olefir: Institute of Biological and Medical Imaging (IBMI), Helmholtz Zentrum München
Stefan Stangl: Klinikum rechts der Isar, Technische Universität München
Panagiotis Symvoulidis: Institute of Biological and Medical Imaging (IBMI), Helmholtz Zentrum München
Sarah Glasl: Institute of Biological and Medical Imaging (IBMI), Helmholtz Zentrum München
Christine Bayer: Klinikum rechts der Isar, Technische Universität München
Gabriele Multhoff: Klinikum rechts der Isar, Technische Universität München
Vasilis Ntziachristos: Institute of Biological and Medical Imaging (IBMI), Helmholtz Zentrum München

Nature Communications, 2016, vol. 7, issue 1, 1-10

Abstract: Abstract Light propagating in tissue attains a spectrum that varies with location due to wavelength-dependent fluence attenuation, an effect that causes spectral corruption. Spectral corruption has limited the quantification accuracy of optical and optoacoustic spectroscopic methods, and impeded the goal of imaging blood oxygen saturation (sO2) deep in tissues; a critical goal for the assessment of oxygenation in physiological processes and disease. Here we describe light fluence in the spectral domain and introduce eigenspectra multispectral optoacoustic tomography (eMSOT) to account for wavelength-dependent light attenuation, and estimate blood sO2 within deep tissue. We validate eMSOT in simulations, phantoms and animal measurements and spatially resolve sO2 in muscle and tumours, validating our measurements with histology data. eMSOT shows substantial sO2 accuracy enhancement over previous optoacoustic methods, potentially serving as a valuable tool for imaging tissue pathophysiology.

Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/ncomms12121 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12121

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms12121

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().