Envelope-specific B-cell populations in African green monkeys chronically infected with simian immunodeficiency virus

Ruijun Zhang, David R. Martinez, Quang N. Nguyen, Justin Pollara, Trina Arifin, Christina Stolarchuk, Andrew Foulger, Josh D. Amos, Robert Parks, Jonathon E. Himes, Minyue Wang, Regina W. Edwards, Ashley M. Trama, Nathan Vandergrift, Lisa Colvin, Ken Dewar, Nikoleta Juretic, Jessica Wasserscheid, Guido Ferrari, Hua-Xin Liao () and Sallie R. Permar ()
Additional contact information
Ruijun Zhang: Duke Human Vaccine Institute, Duke University School of Medicine
David R. Martinez: Duke Human Vaccine Institute, Duke University School of Medicine
Quang N. Nguyen: Duke Human Vaccine Institute, Duke University School of Medicine
Justin Pollara: Duke Human Vaccine Institute, Duke University School of Medicine
Trina Arifin: Duke Human Vaccine Institute, Duke University School of Medicine
Christina Stolarchuk: Duke Human Vaccine Institute, Duke University School of Medicine
Andrew Foulger: Duke Human Vaccine Institute, Duke University School of Medicine
Josh D. Amos: Duke Human Vaccine Institute, Duke University School of Medicine
Robert Parks: Duke Human Vaccine Institute, Duke University School of Medicine
Jonathon E. Himes: Duke Human Vaccine Institute, Duke University School of Medicine
Minyue Wang: Duke Human Vaccine Institute, Duke University School of Medicine
Regina W. Edwards: Duke Human Vaccine Institute, Duke University School of Medicine
Ashley M. Trama: Duke Human Vaccine Institute, Duke University School of Medicine
Nathan Vandergrift: Duke Human Vaccine Institute, Duke University School of Medicine
Lisa Colvin: Duke Human Vaccine Institute, Duke University School of Medicine
Ken Dewar: Research Institute of the McGill University Health Centre, McGill University and Génome Québec Innovation Centre
Nikoleta Juretic: Research Institute of the McGill University Health Centre, McGill University and Génome Québec Innovation Centre
Jessica Wasserscheid: Research Institute of the McGill University Health Centre, McGill University and Génome Québec Innovation Centre
Guido Ferrari: Duke Human Vaccine Institute, Duke University School of Medicine
Hua-Xin Liao: Duke Human Vaccine Institute, Duke University School of Medicine
Sallie R. Permar: Duke Human Vaccine Institute, Duke University School of Medicine

Nature Communications, 2016, vol. 7, issue 1, 1-11

Abstract: Abstract African green monkeys (AGMs) are natural primate hosts of simian immunodeficiency virus (SIV). Interestingly, features of the envelope-specific antibody responses in SIV-infected AGMs are distinct from that of HIV-infected humans and SIV-infected rhesus monkeys, including gp120-focused responses and rapid development of autologous neutralization. Yet, the lack of genetic tools to evaluate B-cell lineages hinders potential use of this unique non-human primate model for HIV vaccine development. Here we define features of the AGM Ig loci and compare the proportion of Env-specific memory B-cell populations to that of HIV-infected humans and SIV-infected rhesus monkeys. AGMs appear to have a higher proportion of Env-specific memory B cells that are mainly gp120 directed. Furthermore, AGM gp120-specific monoclonal antibodies display robust antibody-dependent cellular cytotoxicity and CD4-dependent virion capture activity. Our results support the use of AGMs to model induction of functional gp120-specific antibodies by HIV vaccine strategies.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12131

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DOI: 10.1038/ncomms12131

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