αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development

Chun-Ying Li (), Jimmy Hu, Hongbing Lu, Jing Lan, Wei Du, Nicole Galicia and Ophir D. Klein ()
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Chun-Ying Li: Zhongshan Hospital of Dalian University
Jimmy Hu: University of California
Hongbing Lu: University of California
Jing Lan: University of California
Wei Du: University of California
Nicole Galicia: University of California
Ophir D. Klein: University of California

Nature Communications, 2016, vol. 7, issue 1, 1-13

Abstract: Abstract Embryonic signalling centres are specialized clusters of non-proliferating cells that direct the development of many organs. However, the mechanisms that establish these essential structures in mammals are not well understood. Here we report, using the murine incisor as a model, that αE-catenin is essential for inhibiting nuclear YAP localization and cell proliferation. This function of αE-catenin is required for formation of the tooth signalling centre, the enamel knot (EK), which maintains dental mesenchymal condensation and epithelial invagination. EK formation depends primarily on the signalling function of αE-catenin through YAP and its homologue TAZ, as opposed to its adhesive function, and combined deletion of Yap and Taz rescues the EK defects caused by loss of αE-catenin. These findings point to a developmental mechanism by which αE-catenin restricts YAP/TAZ activity to establish a group of non-dividing and specialized cells that constitute a signalling centre.

Date: 2016
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DOI: 10.1038/ncomms12133

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