A heavy metal P-type ATPase OsHMA4 prevents copper accumulation in rice grain

Xin-Yuan Huang, Fenglin Deng, Naoki Yamaji, Shannon R.M. Pinson, Miho Fujii-Kashino, John Danku, Alex Douglas, Mary Lou Guerinot, David E. Salt () and Jian Feng Ma ()
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Xin-Yuan Huang: Institute of Biological and Environmental Sciences, University of Aberdeen
Fenglin Deng: Institute of Plant Science and Resources, Okayama University
Naoki Yamaji: Institute of Plant Science and Resources, Okayama University
Shannon R.M. Pinson: USDA–ARS Dale Bumpers National Rice Research Center
Miho Fujii-Kashino: Institute of Plant Science and Resources, Okayama University
John Danku: Institute of Biological and Environmental Sciences, University of Aberdeen
Alex Douglas: Institute of Biological and Environmental Sciences, University of Aberdeen
Mary Lou Guerinot: Dartmouth College
David E. Salt: Institute of Biological and Environmental Sciences, University of Aberdeen
Jian Feng Ma: Institute of Plant Science and Resources, Okayama University

Nature Communications, 2016, vol. 7, issue 1, 1-13

Abstract: Abstract Rice is a major source of calories and mineral nutrients for over half the world’s human population. However, little is known in rice about the genetic basis of variation in accumulation of copper (Cu), an essential but potentially toxic nutrient. Here we identify OsHMA4 as the likely causal gene of a quantitative trait locus controlling Cu accumulation in rice grain. We provide evidence that OsHMA4 functions to sequester Cu into root vacuoles, limiting Cu accumulation in the grain. The difference in grain Cu accumulation is most likely attributed to a single amino acid substitution that leads to different OsHMA4 transport activity. The allele associated with low grain Cu was found in 67 of the 1,367 rice accessions investigated. Identification of natural allelic variation in OsHMA4 may facilitate the development of rice varieties with grain Cu concentrations tuned to both the concentration of Cu in the soil and dietary needs.

Date: 2016
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DOI: 10.1038/ncomms12138

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