Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus

Pierre Martinez, Margriet R. Timmer, Chiu T. Lau, Silvia Calpe, Maria del Carmen Sancho-Serra, Danielle Straub, Ann-Marie Baker, Sybren L. Meijer, Fiebo J. W. ten Kate, Rosalie C. Mallant-Hent, Anton H. J. Naber, Arnoud H. A. M. van Oijen, Lubbertus C. Baak, Pieter Scholten, Clarisse J. M. Böhmer, Paul Fockens, Jacques J. G. H. M. Bergman, Carlo C. Maley (), Trevor A. Graham () and Kausilia K Krishnadath ()
Additional contact information
Pierre Martinez: Evolution and Cancer Laboratory, Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London
Margriet R. Timmer: Academic Medical Center—University of Amsterdam
Chiu T. Lau: Academic Medical Center—University of Amsterdam
Silvia Calpe: Academic Medical Center—University of Amsterdam
Maria del Carmen Sancho-Serra: Academic Medical Center—University of Amsterdam
Danielle Straub: Academic Medical Center—University of Amsterdam
Ann-Marie Baker: Evolution and Cancer Laboratory, Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London
Sybren L. Meijer: Academic Medical Center—University of Amsterdam
Fiebo J. W. ten Kate: Academic Medical Center—University of Amsterdam
Rosalie C. Mallant-Hent: Flevoziekenhuis
Anton H. J. Naber: Gastroenterological Association
Arnoud H. A. M. van Oijen: Gastroenterological Association
Lubbertus C. Baak: Gastroenterological Association
Pieter Scholten: Gastroenterological Association
Clarisse J. M. Böhmer: Gastroenterological Association
Paul Fockens: Academic Medical Center—University of Amsterdam
Jacques J. G. H. M. Bergman: Academic Medical Center—University of Amsterdam
Carlo C. Maley: Biodesign Institute, School of Life Sciences, Arizona State University
Trevor A. Graham: Evolution and Cancer Laboratory, Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London
Kausilia K Krishnadath: Academic Medical Center—University of Amsterdam

Nature Communications, 2016, vol. 7, issue 1, 1-10

Abstract: Abstract Surveillance of Barrett’s oesophagus allows us to study the evolutionary dynamics of a human neoplasm over time. Here we use multicolour fluorescence in situ hybridization on brush cytology specimens, from two time points with a median interval of 37 months in 195 non-dysplastic Barrett's patients, and a third time point in a subset of 90 patients at a median interval of 36 months, to study clonal evolution at single-cell resolution. Baseline genetic diversity predicts progression and remains in a stable dynamic equilibrium over time. Clonal expansions are rare, being detected once every 36.8 patient years, and growing at an average rate of 1.58 cm2 (95% CI: 0.09–4.06) per year, often involving the p16 locus. This suggests a lack of strong clonal selection in Barrett’s and that the malignant potential of ‘benign’ Barrett’s lesions is predetermined, with important implications for surveillance programs.

Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/ncomms12158 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12158

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms12158

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().