Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway

Ruani N. Fernando, Laurent Cotter, Claire Perrin-Tricaud, Jade Berthelot, Sylvain Bartolami, Jorge A. Pereira, Sergio Gonzalez, Ueli Suter and Nicolas Tricaud ()
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Ruani N. Fernando: Institut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint Eloi
Laurent Cotter: Institut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint Eloi
Claire Perrin-Tricaud: Institut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint Eloi
Jade Berthelot: Institut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint Eloi
Sylvain Bartolami: Institut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint Eloi
Jorge A. Pereira: ETH, Institute of Molecular Health Sciences
Sergio Gonzalez: Institut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint Eloi
Ueli Suter: ETH, Institute of Molecular Health Sciences
Nicolas Tricaud: Institut des Neurosciences de Montpellier, INSERM U1051, University of Montpellier, Hopital Saint Eloi

Nature Communications, 2016, vol. 7, issue 1, 1-14

Abstract: Abstract Fast nerve conduction relies on successive myelin segments that electrically isolate axons. Segment geometry—diameter and length—is critical for the optimization of nerve conduction and the molecular mechanisms allowing this optimized geometry are partially known. We show here that peripheral myelin elongation is dynamically regulated by stimulation of YAP (Yes-associated protein) transcription cofactor activity during axonal elongation and limited by inhibition of YAP activity via the Hippo pathway. YAP promotes myelin and non-myelin genes transcription while the polarity protein Crb3, localized at the tips of the myelin sheath, activates the Hippo pathway to temper YAP activity, therefore allowing for optimal myelin growth. Dystrophic Dy2j/2j mice mimicking human peripheral neuropathy with reduced internodal lengths have decreased nuclear YAP which, when corrected, leads to longer internodes. These data show a novel mechanism controlling myelin growth and nerve conduction, and provide a molecular ground for disease with short myelin segments.

Date: 2016
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DOI: 10.1038/ncomms12186

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