A rhesus macaque model of Asian-lineage Zika virus infection

Dawn M. Dudley, Matthew T. Aliota, Emma L. Mohr, Andrea M. Weiler, Gabrielle Lehrer-Brey, Kim L. Weisgrau, Mariel S. Mohns, Meghan E. Breitbach, Mustafa N. Rasheed, Christina M. Newman, Dane D. Gellerup, Louise H. Moncla, Jennifer Post, Nancy Schultz-Darken, Michele L. Schotzko, Jennifer M. Hayes, Josh A. Eudailey, M. Anthony Moody, Sallie R. Permar, Shelby L. O’Connor, Eva G. Rakasz, Heather A. Simmons, Saverio Capuano, Thaddeus G. Golos, Jorge E. Osorio, Thomas C. Friedrich and David H. O’Connor ()
Additional contact information
Dawn M. Dudley: University of Wisconsin-Madison
Matthew T. Aliota: University of Wisconsin-Madison
Emma L. Mohr: School of Medicine and Public Health, University of Wisconsin-Madison
Andrea M. Weiler: Wisconsin National Primate Research Center, University of Wisconsin-Madison
Gabrielle Lehrer-Brey: Wisconsin National Primate Research Center, University of Wisconsin-Madison
Kim L. Weisgrau: Wisconsin National Primate Research Center, University of Wisconsin-Madison
Mariel S. Mohns: University of Wisconsin-Madison
Meghan E. Breitbach: University of Wisconsin-Madison
Mustafa N. Rasheed: University of Wisconsin-Madison
Christina M. Newman: University of Wisconsin-Madison
Dane D. Gellerup: Wisconsin National Primate Research Center, University of Wisconsin-Madison
Louise H. Moncla: University of Wisconsin-Madison
Jennifer Post: Wisconsin National Primate Research Center, University of Wisconsin-Madison
Nancy Schultz-Darken: Wisconsin National Primate Research Center, University of Wisconsin-Madison
Michele L. Schotzko: Wisconsin National Primate Research Center, University of Wisconsin-Madison
Jennifer M. Hayes: Wisconsin National Primate Research Center, University of Wisconsin-Madison
Josh A. Eudailey: Duke University Medical Center
M. Anthony Moody: Duke University Medical Center
Sallie R. Permar: Duke University Medical Center
Shelby L. O’Connor: University of Wisconsin-Madison
Eva G. Rakasz: Wisconsin National Primate Research Center, University of Wisconsin-Madison
Heather A. Simmons: Wisconsin National Primate Research Center, University of Wisconsin-Madison
Saverio Capuano: Wisconsin National Primate Research Center, University of Wisconsin-Madison
Thaddeus G. Golos: Wisconsin National Primate Research Center, University of Wisconsin-Madison
Jorge E. Osorio: University of Wisconsin-Madison
Thomas C. Friedrich: University of Wisconsin-Madison
David H. O’Connor: University of Wisconsin-Madison

Nature Communications, 2016, vol. 7, issue 1, 1-9

Abstract: Abstract Infection with Asian-lineage Zika virus (ZIKV) has been associated with Guillain–Barré syndrome and fetal abnormalities, but the underlying mechanisms remain poorly understood. Animal models of infection are thus urgently needed. Here we show that rhesus macaques are susceptible to infection by an Asian-lineage ZIKV closely related to strains currently circulating in the Americas. Following subcutaneous inoculation, ZIKV RNA is detected in plasma 1 day post infection (d.p.i.) in all animals (N=8, including 2 pregnant animals), and is also present in saliva, urine and cerebrospinal fluid. Non-pregnant and pregnant animals remain viremic for 21 days and for up to at least 57 days, respectively. Neutralizing antibodies are detected by 21 d.p.i. Rechallenge 10 weeks after the initial challenge results in no detectable virus replication, indicating protective immunity against homologous strains. Therefore, Asian-lineage ZIKV infection of rhesus macaques provides a relevant animal model for studying pathogenesis and evaluating potential interventions against human infection, including during pregnancy.

Date: 2016
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DOI: 10.1038/ncomms12204

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