Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs

Maoyi Lai, Alicia Gonzalez-Martin, Anthony B. Cooper, Hiroyo Oda, Hyun Yong Jin, Jovan Shepherd, Linling He, Jiang Zhu, David Nemazee () and Changchun Xiao ()
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Maoyi Lai: The Scripps Research Institute
Alicia Gonzalez-Martin: The Scripps Research Institute
Anthony B. Cooper: The Scripps Research Institute
Hiroyo Oda: The Scripps Research Institute
Hyun Yong Jin: The Scripps Research Institute
Jovan Shepherd: The Scripps Research Institute
Linling He: The Scripps Research Institute
Jiang Zhu: The Scripps Research Institute
David Nemazee: The Scripps Research Institute
Changchun Xiao: The Scripps Research Institute

Nature Communications, 2016, vol. 7, issue 1, 1-13

Abstract: Abstract The molecular mechanisms that regulate B-cell development and tolerance remain incompletely understood. In this study, we identify a critical role for the miR-17∼92 microRNA cluster in regulating B-cell central tolerance and demonstrate that these miRNAs control early B-cell development in a cell-intrinsic manner. While the cluster member miR-19 suppresses the expression of Pten and plays a key role in regulating B-cell tolerance, miR-17 controls early B-cell development through other molecular pathways. These findings demonstrate differential control of two closely linked B-cell developmental stages by different members of a single microRNA cluster through distinct molecular pathways.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12207

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DOI: 10.1038/ncomms12207

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