Molecular signatures of neural connectivity in the olfactory cortex

Assunta Diodato, Marion Ruinart de Brimont, Yeong Shin Yim, Nicolas Derian, Sandrine Perrin, Juliette Pouch, David Klatzmann, Sonia Garel, Gloria B Choi and Alexander Fleischmann ()
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Assunta Diodato: Center for Interdisciplinary Research in Biology (CIRB), Collège de France, and CNRS, UMR 7241 and INSERM U1050
Marion Ruinart de Brimont: Center for Interdisciplinary Research in Biology (CIRB), Collège de France, and CNRS, UMR 7241 and INSERM U1050
Yeong Shin Yim: McGovern Institute for Brain Research, Massachusetts Institute of Technology
Nicolas Derian: Sorbonne Universités, UPMC Univ Paris 06, INSERM U959, Immunology-Immunopathology-Immunotherapy (I3), and AP-HP, Clinical Investigation Center in Biotherapy
Sandrine Perrin: École Normale Supérieure, Institut de Biologie de l’ENS, Plateforme Génomique, and INSERM U1024, CNRS UMR 8197
Juliette Pouch: École Normale Supérieure, Institut de Biologie de l’ENS, Plateforme Génomique, and INSERM U1024, CNRS UMR 8197
David Klatzmann: Sorbonne Universités, UPMC Univ Paris 06, INSERM U959, Immunology-Immunopathology-Immunotherapy (I3), and AP-HP, Clinical Investigation Center in Biotherapy
Sonia Garel: École Normale Supérieure, Institut de Biologie de l’ENS, and INSERM U1024, CNRS UMR 8197
Gloria B Choi: McGovern Institute for Brain Research, Massachusetts Institute of Technology
Alexander Fleischmann: Center for Interdisciplinary Research in Biology (CIRB), Collège de France, and CNRS, UMR 7241 and INSERM U1050

Nature Communications, 2016, vol. 7, issue 1, 1-10

Abstract: Abstract The ability to target subclasses of neurons with defined connectivity is crucial for uncovering neural circuit functions. The olfactory (piriform) cortex is thought to generate odour percepts and memories, and odour information encoded in piriform is routed to target brain areas involved in multimodal sensory integration, cognition and motor control. However, it remains unknown if piriform outputs are spatially organized, and if distinct output channels are delineated by different gene expression patterns. Here we identify genes selectively expressed in different layers of the piriform cortex. Neural tracing experiments reveal that these layer-specific piriform genes mark different subclasses of neurons, which project to distinct target areas. Interestingly, these molecular signatures of connectivity are maintained in reeler mutant mice, in which neural positioning is scrambled. These results reveal that a predictive link between a neuron’s molecular identity and connectivity in this cortical circuit is determined independent of its spatial position.

Date: 2016
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DOI: 10.1038/ncomms12238

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