Protein kinase A modulation of CaV1.4 calcium channels

Lingjie Sang, Ivy E. Dick () and David T. Yue
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Lingjie Sang: Calcium Signals Laboratory, The Johns Hopkins University School of Medicine
Ivy E. Dick: Calcium Signals Laboratory, The Johns Hopkins University School of Medicine
David T. Yue: Calcium Signals Laboratory, The Johns Hopkins University School of Medicine

Nature Communications, 2016, vol. 7, issue 1, 1-11

Abstract: Abstract The regulation of L-type Ca2+ channels by protein kinase A (PKA) represents a crucial element within cardiac, skeletal muscle and neurological systems. Although much work has been done to understand this regulation in cardiac CaV1.2 Ca2+ channels, relatively little is known about the closely related CaV1.4 L-type Ca2+ channels, which feature prominently in the visual system. Here we find that CaV1.4 channels are indeed modulated by PKA phosphorylation within the inhibitor of Ca2+-dependent inactivation (ICDI) motif. Phosphorylation of this region promotes the occupancy of calmodulin on the channel, thus increasing channel open probability (PO) and Ca2+-dependent inactivation. Although this interaction seems specific to CaV1.4 channels, introduction of ICDI1.4 to CaV1.3 or CaV1.2 channels endows these channels with a form of PKA modulation, previously unobserved in heterologous systems. Thus, this mechanism may not only play an important role in the visual system but may be generalizable across the L-type channel family.

Date: 2016
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DOI: 10.1038/ncomms12239

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