Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids

Haibao Jin, Fang Jiao, Michael D. Daily, Yulin Chen, Feng Yan, Yan-Huai Ding, Xin Zhang, Ellen J. Robertson, Marcel D. Baer and Chun-Long Chen ()
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Haibao Jin: Pacific Northwest National Laboratory
Fang Jiao: Pacific Northwest National Laboratory
Michael D. Daily: Pacific Northwest National Laboratory
Yulin Chen: Pacific Northwest National Laboratory
Feng Yan: Pacific Northwest National Laboratory
Yan-Huai Ding: Pacific Northwest National Laboratory
Xin Zhang: Pacific Northwest National Laboratory
Ellen J. Robertson: Molecular Foundry, Lawrence Berkeley National Laboratory
Marcel D. Baer: Pacific Northwest National Laboratory
Chun-Long Chen: Pacific Northwest National Laboratory

Nature Communications, 2016, vol. 7, issue 1, 1-8

Abstract: Abstract An ability to develop sequence-defined synthetic polymers that both mimic lipid amphiphilicity for self-assembly of highly stable membrane-mimetic 2D nanomaterials and exhibit protein-like functionality would revolutionize the development of biomimetic membranes. Here we report the assembly of lipid-like peptoids into highly stable, crystalline, free-standing and self-repairing membrane-mimetic 2D nanomaterials through a facile crystallization process. Both experimental and molecular dynamics simulation results show that peptoids assemble into membranes through an anisotropic formation process. We further demonstrated the use of peptoid membranes as a robust platform to incorporate and pattern functional objects through large side-chain diversity and/or co-crystallization approaches. Similar to lipid membranes, peptoid membranes exhibit changes in thickness upon exposure to external stimuli; they can coat surfaces in single layers and self-repair. We anticipate that this new class of membrane-mimetic 2D nanomaterials will provide a robust matrix for development of biomimetic membranes tailored to specific applications.

Date: 2016
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DOI: 10.1038/ncomms12252

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