Cavity optomechanical spring sensing of single molecules

Wenyan Yu, Wei C Jiang, Qiang Lin () and Tao Lu ()
Additional contact information
Wenyan Yu: University of Victoria
Wei C Jiang: Institute of Optics, University of Rochester
Qiang Lin: Institute of Optics, University of Rochester
Tao Lu: University of Victoria

Nature Communications, 2016, vol. 7, issue 1, 1-9

Abstract: Abstract Label-free bio-sensing is a critical functionality underlying a variety of health- and security-related applications. Micro-/nano-photonic devices are well suited for this purpose and have emerged as promising platforms in recent years. Here we propose and demonstrate an approach that utilizes the optical spring effect in a high-Q coherent optomechanical oscillator to dramatically enhance the sensing resolution by orders of magnitude compared with conventional approaches, allowing us to detect single bovine serum albumin proteins with a molecular weight of 66 kDa at a signal-to-noise ratio of 16.8. The unique optical spring sensing approach opens up a distinctive avenue that not only enables biomolecule sensing and recognition at individual level, but is also of great promise for broad physical sensing applications that rely on sensitive detection of optical cavity resonance shift to probe external physical parameters.

Date: 2016
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms12311 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12311

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms12311

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().