Cellular tagging as a neural network mechanism for behavioural tagging

Masanori Nomoto, Noriaki Ohkawa, Hirofumi Nishizono, Jun Yokose, Akinobu Suzuki, Mina Matsuo, Shuhei Tsujimura, Yukari Takahashi, Masashi Nagase, Ayako M. Watabe, Fusao Kato and Kaoru Inokuchi ()
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Masanori Nomoto: Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
Noriaki Ohkawa: Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
Hirofumi Nishizono: CREST, JST, University of Toyama
Jun Yokose: Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
Akinobu Suzuki: Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
Mina Matsuo: Life Science Research Center, University of Toyama
Shuhei Tsujimura: Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
Yukari Takahashi: Jikei University School of Medicine
Masashi Nagase: Jikei University School of Medicine
Ayako M. Watabe: Jikei University School of Medicine
Fusao Kato: Jikei University School of Medicine
Kaoru Inokuchi: Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama

Nature Communications, 2016, vol. 7, issue 1, 1-11

Abstract: Abstract Behavioural tagging is the transformation of a short-term memory, induced by a weak experience, into a long-term memory (LTM) due to the temporal association with a novel experience. The mechanism by which neuronal ensembles, each carrying a memory engram of one of the experiences, interact to achieve behavioural tagging is unknown. Here we show that retrieval of a LTM formed by behavioural tagging of a weak experience depends on the degree of overlap with the neuronal ensemble corresponding to a novel experience. The numbers of neurons activated by weak training in a novel object recognition (NOR) task and by a novel context exploration (NCE) task, denoted as overlapping neurons, increases in the hippocampal CA1 when behavioural tagging is successfully achieved. Optical silencing of an NCE-related ensemble suppresses NOR–LTM retrieval. Thus, a population of cells recruited by NOR is tagged and then preferentially incorporated into the memory trace for NCE to achieve behavioural tagging.

Date: 2016
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DOI: 10.1038/ncomms12319

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