Chromatin remodelling and antisense-mediated up-regulation of the developmental switch gene eud-1 control predatory feeding plasticity

Vahan Serobyan, Hua Xiao, Suryesh Namdeo, Christian Rödelsperger, Bogdan Sieriebriennikov, Hanh Witte, Waltraud Röseler and Ralf J. Sommer ()
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Vahan Serobyan: Max-Planck-Institute for Developmental Biology
Hua Xiao: Max-Planck-Institute for Developmental Biology
Suryesh Namdeo: Max-Planck-Institute for Developmental Biology
Christian Rödelsperger: Max-Planck-Institute for Developmental Biology
Bogdan Sieriebriennikov: Max-Planck-Institute for Developmental Biology
Hanh Witte: Max-Planck-Institute for Developmental Biology
Waltraud Röseler: Max-Planck-Institute for Developmental Biology
Ralf J. Sommer: Max-Planck-Institute for Developmental Biology

Nature Communications, 2016, vol. 7, issue 1, 1-8

Abstract: Abstract Phenotypic plasticity has been suggested to act through developmental switches, but little is known about associated molecular mechanisms. In the nematode Pristionchus pacificus, the sulfatase eud-1 was identified as part of a developmental switch controlling mouth-form plasticity governing a predatory versus bacteriovorous mouth-form decision. Here we show that mutations in the conserved histone-acetyltransferase Ppa-lsy-12 and the methyl-binding-protein Ppa-mbd-2 mimic the eud-1 phenotype, resulting in the absence of one mouth-form. Mutations in both genes cause histone modification defects and reduced eud-1 expression. Surprisingly, Ppa-lsy-12 mutants also result in the down-regulation of an antisense-eud-1 RNA. eud-1 and antisense-eud-1 are co-expressed and further experiments suggest that antisense-eud-1 acts through eud-1 itself. Indeed, overexpression of the antisense-eud-1 RNA increases the eud-1-sensitive mouth-form and extends eud-1 expression. In contrast, this effect is absent in eud-1 mutants indicating that antisense-eud-1 positively regulates eud-1. Thus, chromatin remodelling and antisense-mediated up-regulation of eud-1 control feeding plasticity in Pristionchus.

Date: 2016
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DOI: 10.1038/ncomms12337

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